Dr. Pramod B. Shinde

Designation: Sr. Scientist
Phone No:
2567760
Phone Ext. No: 6470
E-Mail: pramodshinde[at]csmcri.res.in

Research Activities


Natural Products Drug Discovery: Potential drug leads from marine and terrestrial resources (plants, microorganisms, sponges, corals, tunicate, starfish, etc), Natural Products Biosynthesis: Elucidation of biosynthetic pathways, Chemical ecology: Microbe-plant, microbe-marine invertebrate, and microbe-insect symbiosis


Expertise


Isolation and structure determination of secondary metabolites utilizing chromatographic separation and spectroscopic analysis (1D and 2D NMR and MS, MS/MS, HR-MS), Isolation and identification of symbiotic microorganisms


Personal Webpage: Click Here

PUBLICATIONS IN LAST 5 YEARS:

1. Pramod B. Shinde, Hong-Se Oh, Hyemin Choi, Kris Rathwell, Yeon Hee Ban, Eun-Ji Kim, Inho Yang, Dong Gun Lee, David H. Sherman, Han-Young Kang, Yeo Joon Yoon; Chemoenzymatic synthesis of glycosylated macrolactam analogues of macrolide antibiotic YC-17. Adv. Synth. Catal. 2015, 357, 2697-2711.

2. Pramod B. Shinde, Yeon Hee Ban, Jae-yeon Hwang, Yumi Cho, Yi-Ahn Chen, Eunji Cheong, Sang-Jip Nam, Ho Jeong Kwon, Yeo Joon Yoon; A non-immunosuppressive FK506 analogue with neuroregenerative activity from a genetically engineered Streptomyces strain. RSC Adv. 2015, 5, 6823-6828.

3. Pramod B. Shinde, Ah Reum Han, Jaeyong Cho, So Ra Lee, Yeon Hee Ban, Young Ji Yoo, Eun Ji Kim, Eunji Kim, Dong Gun Lee, Yeo Joon Yoon; Combinatorial biosynthesis and antibacterial evaluation of 12-membered macrolide antibiotic YC-17. J. Biotech. 2013, 168, 142-148.

4. Yeon Hee Ban, Pramod B. Shinde, Jae-yeon Hwang, Myoung-Chong Song, Dong Hwan Kim, Si-Kyu Lim, Jae Kyung Sohng, Yeo Joon Yoon; Characterization of FK506 biosynthetic intermediates involved in post-PKS elaboration. J. Nat. Prod. 2013, 76, 1091-1098 . (joint first author)

5. Ah Reum Han, Pramod B. Shinde, Je Won Park, Jaeyong Cho, So Ra Lee, Yeon Hee Ban, Young Ji Yoo, Eun Ji Kim, Eunji Kim, Sung Ryeol Park, Byung-Gee Kim, Dong Gun Lee, Yeo Joon Yoon; Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities. App. Microbiol. Biotech. 2012, 93, 1147-1156. (joint first author)

PATENTS

1.  FK506 derivatives maintaining nerve regeneration activity and use   thereof, International Patent WO 2016018117A1.

2. Novel macrolactam glycoside derivatives, their preparation and chemical-enzymatic antimicrobial composition comprising the same, Repub. Korean Kongkae Taeho Kongbo KR patent application no. 10-2015-0041656 (06.05.2015).

3. Nerve regeneration activity of FK506 derivatives and their use without Immunosuppression, Repub. Korean Kongkae Taeho Kongbo KR patent application no. 10-2014-0099210 (01.08.2014).

4. Narbomycin derivative, its producing method, and antibacterial composition comprising the same, Repub. Korean Kongkae Taeho Kongbo (2012), KR 2012117568 A 20121024.

PRESENTATIONS (CONFERENCES / INVITED TALKS / POSTER) in last 5 years:

1. Pramod B. Shinde;Engineering biosynthesis of glycosylated derivatives of macrolide antibiotics”, presented at Bioprocessing India 2014, Institute of Chemical Technology Mumbai, December 17-20, 2014 at Mumbai, India.

2. Shiying Jin, Pramod B. Shinde, Yeon Hee Ban, Hea Lyung Shin, Jaeyeon Hwang, Eun Young Ahn, Hang Soo Cho, Yeo Joon Yoon; "Engineered Biosynthesis of Glycosylated Derivatives: 12-Membered Macrolide Antibiotic YC-17" Presented at Korean Society of Biological Chemistry 2014 International Symposium and Annual Meeting, October 30-31, 2014 at KINTEX, Ilsan, Korea

3. Hea Lyung Shin, Pramod B. Shinde, Yeon Hee Ban, Eunji Kim, Jaeyeon Hwang, Shiying Jin, Jin A Jung, Yeo Joon Yoon "Structural Characterization of Cyclosporine A, C and Microbial Bio-converted Cyclosporine A Analog AM6, Using HPLC-ESI-ion Trap-mass Spectrometry" Presented at Korean Society of Microbiology and Biotechnology 2014 International Symposium and Annual Meeting, June 25-27, 2014 at BEXCO, Busan, Korea

4. Jaeyeon Hwang, Pramod B. Shinde, EunJi Kim, Hea Lyung Shin, Shiying Jin, Eun Young Ahn, Hang Soo Cho, Yeo Joon Yoon; "Elucidation of Post-Polyketide Synthase Modification Enzymes in FK506 Biosynthetic Pathway" Presented at The 7th Japan-Korea Chemical Biology Symposium, February 09-11, 2014 at The-K JEJU Hotel, Jeju-do, Korea.

5. EunJi Kim, Pramod B. Shinde, Young Ji Yoo, Heqing Cui, Myoun Su Kim, Ji Yoon Beom, Yeo Joon Yoon; “Combinatorial biosynthesis of the glycosylated derivatives of anthracycline anticancer by using a substrate flexible glycosyltransferase”, presented at International Meeting of the Federation of Korean Microbiological Societies, October 17-18, 2013 at The-K Seoul Hotel, Seoul, South Korea.

6. Heqing Cui, Young Ji Yoo, Eun Ji Kim, Hea Lyung Shin, Ji Yoon Beom, Pramod B. Shinde, Yeo Joon Yoon; “Post-PKS modification steps of FK506 biosynthesis”, presented at Korean Society of Biotechnology and Bioengineering Fall Meeting and International Symposium, October 16-18, 2013 at BEXCO, Busan, South Korea.

7. Pramod B. Shinde;Natural products drug discovery through biosynthetic pathway engineering”, presented at Department of Chemistry, Indian Institute of Technology Delhi, on August 13, 2013 at Delhi, India.

8. Jaeyeon Hwang, Pramod B. Shinde, Dinesh Koju, Yeon Hee Ban, Eun Young Ahn, Hang Soo Cho, Yeo Joon Yoon; “Regulation of FK506 production in Streptomyces sp. Strain KCTC 11604BP”, presented at Korean Society of Microbiology and Biotechnology 2013 International Symposium and Annual Meeting, July 03-05, 2013 at Alpensia, Pyeongchang, South Korea.

9. Eun Young Ahn, Pramod B shinde, Young Ji Yoo, Eunji Kim, Jae Yeon Hwang, Heqing Cui, Myoun Su Kim, Yeo Joon Yoon; "Generation of narbomycin derivatives and their antibacterial activity tests”, presented at 2013 Korean Society of Biotechnology and Bioengineering Spring Meeting and International Symposium, April 10-12, 2013 at at K. D. J. Center, Kwangju, South Korea.

10. Pramod B. Shinde, Ah Reum Han, Jaeyong Cho, So Ra Lee, Yeon Hee Ban, Young Ji Yoo, Eun Ji Kim, Eunji Kim, Je Won Park, Dong Gun Lee, Yeo Joon Yoon; “Combinatorial biosynthesis and antibacterial evaluation of glycosylated derivatives of 12-membered macrolide antibiotic YC-17”, presented at 15th International Biotechnology Symposium and Exhibition (IBS-2012) Innovative Biotechnology for Green World and Beyond, September, 17-21, 2012 at Daegue, South Korea.

11. Pramod B. Shinde;Drug discovery: Natural products chemistry meets microbial biotechnology”, presented at Department of Biological Environment, College of Agriculture and Life Science, Kangwon National University, on December, 16, 2011 at Chuncheon, South Korea.

12. Ji Yeon Park, Sung Ryeol Park, Pramod B. Shinde, Young Ji Yoo, Eun Ji Kim, Yeo Joon Yoon; “Enhanced flavonoid production in Streptomyces venezuelae via metabolic engineering”, presented at 2011 Korean Society of Biotechnology and Bioengineering Fall meeting and international symposium, October 05-08, 2011 at Songdo Convensia, Incheon, South Korea. 

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